What is Matchright Technology and CADD and how does it work?
Matchright technology is a method used by GenePeeks, a company that pairs sperm donor’s genetic information with the customer’s genetic information. Using algorithmic software, GenePeeks is able to create 10,000 embryonic simulations that are the result of the donor and parent’s paired DNA. They then use Combined Annotation Dependent Depletion (CADD) to count the number of genetic mutations within each virtual baby. CADD works by scanning each “baby’s” genomes, in this case the 10,000 virtual embryos. Then they find the amount of harmful nucleotide variants that are present in the genome. GenePeeks then finds the combination of what a donor carries, they then find a customer that has the least likely chance of having a genetic disease. Matchlight Technologies can also determine skin color, eye color, height and waist size, and although GenePeeks does not offer that, there is potential it can be used in the future.
- Written by Morgan H.
Matchright technology is a method used by GenePeeks, a company that pairs sperm donor’s genetic information with the customer’s genetic information. Using algorithmic software, GenePeeks is able to create 10,000 embryonic simulations that are the result of the donor and parent’s paired DNA. They then use Combined Annotation Dependent Depletion (CADD) to count the number of genetic mutations within each virtual baby. CADD works by scanning each “baby’s” genomes, in this case the 10,000 virtual embryos. Then they find the amount of harmful nucleotide variants that are present in the genome. GenePeeks then finds the combination of what a donor carries, they then find a customer that has the least likely chance of having a genetic disease. Matchlight Technologies can also determine skin color, eye color, height and waist size, and although GenePeeks does not offer that, there is potential it can be used in the future.
- Written by Morgan H.
Research Results:
What is Invitro Fertilization (IVF) “test tube babies”?
In vitro fertilization (IVF) is when multiple complex procedures are used to treat problems with things like fertility or genetic problems, and assist with the conception of a child and also making it possible for some people to have children another way. During IVF, mature eggs are collected from the ovaries and fertilized by sperm in a lab. Then the fertilized egg (embryo) or eggs are implanted in the uterus. One cycle of IVF takes about two weeks. IVF is the most successful way to engineer a baby for people who might have medical or personal reasons which is why natural contraception isn’t preferable. IVF can be done by using a partnerships’ sperm and eggs, or it can be done with an anonymous donor. Even though IVF is a huge effective advancement for society today, it can be invasive, expensive and time consuming. The more times you have IVF done the more likely a pregnancy is to occur. Louise Brown who was born in 1978 in England was the first baby to ever be conceived outside the mother’s womb. IVF is different from artificial insemination because it involves taking a sperm and egg into the lab, where it becomes an embryo and later is placed in the uterus to develop. Since 1982 when IVF came to the U.S. more than 200,000 babies have been born from this procedure. Reasons to use IVF can be very broad, but some medical and popular reasons are endometriosis (a lining of the uterine wall outside the uterus), low sperm counts, problems with the uterus or fallopian tubes, problems with ovulation, antibody problems that harm sperm or eggs.
- Written by Audrey E.
How does Invitro Fertilization Work?
In IVF the first step is injecting hormones into the body so that the body can produce multiple eggs each month instead of the usual, which is only one egg. Before you are able to have the egg retrieval done you have to have a medication that prepares your body for ovulation. The timing is very important because the eggs must be retrieved just before they emerge from the follicles in the ovaries, and if the eggs are taken out to late or to early then they won't develop normally. Most women are given pain medication and the choice of being mildly sedated or going under full anesthesia for the procedure of performing IVF. During the procedure the doctor will find the follicles in the ovary with an ultrasound and remove the eggs with a hollow needle. Then right after the retrieval, your eggs will be mixed in the laboratory with the partner's sperm, which had to be donated on the same day. Then the fertilized eggs are kept in the clinic under observation to ensure optimal growth. It can take up to 5 days for the embryo to reach advanced blastocyst stage.
-Written By Audrey E.
In vitro fertilization (IVF) is when multiple complex procedures are used to treat problems with things like fertility or genetic problems, and assist with the conception of a child and also making it possible for some people to have children another way. During IVF, mature eggs are collected from the ovaries and fertilized by sperm in a lab. Then the fertilized egg (embryo) or eggs are implanted in the uterus. One cycle of IVF takes about two weeks. IVF is the most successful way to engineer a baby for people who might have medical or personal reasons which is why natural contraception isn’t preferable. IVF can be done by using a partnerships’ sperm and eggs, or it can be done with an anonymous donor. Even though IVF is a huge effective advancement for society today, it can be invasive, expensive and time consuming. The more times you have IVF done the more likely a pregnancy is to occur. Louise Brown who was born in 1978 in England was the first baby to ever be conceived outside the mother’s womb. IVF is different from artificial insemination because it involves taking a sperm and egg into the lab, where it becomes an embryo and later is placed in the uterus to develop. Since 1982 when IVF came to the U.S. more than 200,000 babies have been born from this procedure. Reasons to use IVF can be very broad, but some medical and popular reasons are endometriosis (a lining of the uterine wall outside the uterus), low sperm counts, problems with the uterus or fallopian tubes, problems with ovulation, antibody problems that harm sperm or eggs.
- Written by Audrey E.
How does Invitro Fertilization Work?
In IVF the first step is injecting hormones into the body so that the body can produce multiple eggs each month instead of the usual, which is only one egg. Before you are able to have the egg retrieval done you have to have a medication that prepares your body for ovulation. The timing is very important because the eggs must be retrieved just before they emerge from the follicles in the ovaries, and if the eggs are taken out to late or to early then they won't develop normally. Most women are given pain medication and the choice of being mildly sedated or going under full anesthesia for the procedure of performing IVF. During the procedure the doctor will find the follicles in the ovary with an ultrasound and remove the eggs with a hollow needle. Then right after the retrieval, your eggs will be mixed in the laboratory with the partner's sperm, which had to be donated on the same day. Then the fertilized eggs are kept in the clinic under observation to ensure optimal growth. It can take up to 5 days for the embryo to reach advanced blastocyst stage.
-Written By Audrey E.
Resources:
Resource 1) - Article
http://cadd.gs.washington.edu/
This website helped me understand what CADD is and how it’s used. It’s only focus is on Combine Annotation Dependent Depletion, and it explains how the software operates and what it can be used for.
- Written by Audrey E.
http://cadd.gs.washington.edu/
This website helped me understand what CADD is and how it’s used. It’s only focus is on Combine Annotation Dependent Depletion, and it explains how the software operates and what it can be used for.
- Written by Audrey E.
Resource 2) - Article
http://www.dailymail.co.uk/sciencetech/article-2601540/See-baby-CONCEIVED-Digital-foetus-created-using-parents-DNA-reveals-diseases-child-develop-ethical.html
This was from the “Science and Tech” section of dailymail.com, the second top selling newspaper in the UK. It describes the overall process of Matchlight Technology, and what GenePeeks does as corperation.
- Written by Audrey E.
http://www.dailymail.co.uk/sciencetech/article-2601540/See-baby-CONCEIVED-Digital-foetus-created-using-parents-DNA-reveals-diseases-child-develop-ethical.html
This was from the “Science and Tech” section of dailymail.com, the second top selling newspaper in the UK. It describes the overall process of Matchlight Technology, and what GenePeeks does as corperation.
- Written by Audrey E.
Resource 3) - Article
http://www.mayoclinic.org/tests-procedures/in-vitro-fertilization/basics/definition/prc-20018905
In this website it talks about in vitro fertilization, and the complex procedures it has when treating fertility or genetic problems that need to be assisted when concepting a child.
-Written by Morgan H.
http://www.mayoclinic.org/tests-procedures/in-vitro-fertilization/basics/definition/prc-20018905
In this website it talks about in vitro fertilization, and the complex procedures it has when treating fertility or genetic problems that need to be assisted when concepting a child.
-Written by Morgan H.
Resource 4) - Video Source
https://www.youtube.com/watch?v=J5AHi4qPZvM
This video is a summary of how GenePeeks was founded, what the company does and how the process works. This helped clarify what GenePeeks accomplished- strategically matching sperm donors with clients so their children won't carry harmful genes.
-Written By Morgan H.
https://www.youtube.com/watch?v=J5AHi4qPZvM
This video is a summary of how GenePeeks was founded, what the company does and how the process works. This helped clarify what GenePeeks accomplished- strategically matching sperm donors with clients so their children won't carry harmful genes.
-Written By Morgan H.
Resource 5) - Video Source
https://www.youtube.com/watch?v=GeigYib39Rs
This video talks about the process of Invitro Fertilization by giving a visual of how it works. The video gives information on risks, cost, and the steps of starting IVF. This 3D animation is very informative.
- Written by Audrey E.
https://www.youtube.com/watch?v=GeigYib39Rs
This video talks about the process of Invitro Fertilization by giving a visual of how it works. The video gives information on risks, cost, and the steps of starting IVF. This 3D animation is very informative.
- Written by Audrey E.
Note- Taking Guide: